Gut microbiota–lncRNA/circRNA crosstalk: implications for different diseases

Abstract

The gut microbiota features an abundance of diverse microorganisms and represents an important component of human physiology and metabolic homeostasis, indicating their roles in a wide array of physiological and pathological processes in the host. Maintaining balance in the gut microbiota is critical for normal functionality as microbial dysbiosis can lead to the occurrence and development of diseases through various mechanisms. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are non-coding RNAs that perform important regulatory functions for many processes. Furthermore, the gut microbiota and lncRNAs/circRNAs are known to interact in a range of both physiological and pathological activities. In this article, we review existing research relevant to the interaction between the gut microbiota and lncRNAs/circRNAs and investigate the role of their crosstalk in the pathogenesis of different diseases. Studies have shown that, the gut microbiota can target lncRNAs ENO1-IT1, BFAL1, and LINC00152 to regulate colorectal cancer development via various signaling pathways. In addition, the gut microbiota can influence mental diseases and lung tumor metastasis by modulating circRNAs such as circNF1-419, circ_0001239, circHIPK2 and mmu_circ_0000730. These findings provide a theoretical basis for disease prevention and treatment and suggest that gut microbiota-lncRNA/circRNA crosstalk has high clinical value.

Keywords:

• Gut microbiota
• lncRNAs
• circRNAs
• crosstalk
• diseases

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Author contributions

LZ drafted the manuscript. XL and HjG edited the manuscript. LZ, Yue Zhang and PfL revised the manuscript. LZ and PL conceived the idea of the review and made the final proof reading. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

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Additional information

Funding

This work was funded by the Natural Science Foundation of Shandong Province, China, grant No. ZR2020QH016 and Integrated Project of Major Research Plan of National Natural Science Foundation of China, grant No.92249303.