Assessment of genotoxicity of glass ionomer cements: a systematic review

Abstract

To evaluate, through a systematic review, the assessment of genotoxicity of glass ionomer cements in vitro and in vivo. A systematic review was performed with the problem, intervention, control, and outcomes (PICOS) strategy, aiming to answer the following question: “Can glass ionomer cements induce genetic damage in vitro and in vivo?” A systematic search was performed in the following electronic databases: PubMed (including MedLine), Web of Science, and Scopus. The quality of included studies was assessed using the Effective Public Health Practice Project (EPHPP). After the authors performed the review of all articles, a total of 13 manuscripts met all the inclusion criteria in the systematic review. Following the parameters of the EPHPP, eight articles were classified as strong or moderate quality. The other ones (five studies) were weak. Taken together our results demonstrated that, six studies reported genotoxicity of the modified glass ionomer cements tested and two studies concluded that the effect of genotoxicity was time dependent.

Keywords:

• Mutagenicity tests
• genetic damage
• genotoxicity
• glass ionomer cements
• dental materials

Acknowledgments

The authors would like to gratefully acknowledge the RNG and LPP, researchers from the Department of Biosciences, Federal University of Sao Paulo, for the critical reading of the manuscript and the Postgraduate Program Interdisciplinary in Health Sciences for the support for the English editing of the final version of this manuscript. Also, the authors would like to acknowledge and thank the anonymous reviewers selected by the Editor for their useful and constructive comments that have improved the final version of the paper.

Author contributions

Study design: ITM, DVS, ACMR, and DAR. Data search: ITM, WMT, DVS, and DAR. Data analysis: ITM, WMT, MRN, OA, and DAR. Writing the paper: ITM, WMT, DVS, MRN, OA, ACMN, and DAR.

Declaration of interest

No potential conflict of interest was reported by the author(s). The authors assume all responsibility for the content reflected in this work. The authors’ affiliations are listed on the title page. All authors have significantly contributed to the preparation of this review. The authors have not participated in and do not anticipate participation in any legal, regulatory, or advocacy proceedings related to the contents of the paper. DAR and ACMR are recipients of CNPq (Conselho Nacional de Desenvolvimento CIentifico e Tecnologico) [Grant number #001].

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.