![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
As a pulmonary cell and as a member of a multisystemic family of mononuclear phagocytes, the alveolar macrophage contributes not only to the maintenance of pulmonary homeostasis but also constitutes a vital link in the general systemic defensive chain. In this review, the role of the macrophage as the ultimate scavenger of the respiratory tree is explored in the context of the variety of environmental and other agents that may disturb this function and thereby injure the host. Analysis of these factors suggests that under conditions of increased inhalant load the macrophagic response is, in most instances, completely adequate to keep the air sacs free from injurious particles and microorganisms. Disturbances of the clearance mechanism induced by toxic injury or overloading of the macrophage may, by permitting the accumulation of harmful chemicals and microorganisms in the lung, contribute to the development of several chronic pulmonary diseases that are associated with our urban-industrial society.