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Abstract
The biliary route is very important for the elimination of some foreign compounds from the body. The current concepts of the physiological mechanisms responsible for the excretion of foreign compounds have been reviewed. For many of the compounds that are extensively excreted into the bile, an increase in the rate at which they are excreted into the bile will decrease their toxicity and a decrease in rate of excretion will increase their toxicity. The effect of a number of factors known to alter the biljary excretion of xenobiotics have been enumerated, such as (a) liver injury; (b) species variation; (c) body temperature; (d) microsomal enzyme induction: (e) chelators; (f) age; and (g) enterohepatic circulation.
The biliary route is very important for the elimination of some foreign compounds from the body. For many of these compounds, an increase in the rate at which they are excreted into the bile will decrease their toxicity and vice versa. A number of factors which are known to alter the biliary excretion of xenobiotics, as well as the current concepts of the physiological mechanisms responsible for the excretion of foreign compounds, have been enumerated. However, much remains still to be understood; essentially nothing is known at the subcellular level about the biliary excretion of foreign compounds. It has recently been concluded8 that our knowledge of the biliary excretion of compounds is about 40 years behind that of the renal excretion mechanism.