The PI3K pathway in B cell metabolism

Abstract

B cell growth and proliferation is tightly regulated by signaling through the B cell receptor and by other membrane bound receptors responding to different cytokines. The PI3K signaling pathway has been shown to play a crucial role in B cell activation, differentiation and survival. Activated B cells undergo metabolic reprograming in response to changing energetic and biosynthetic demands. B cells also need to be able to coordinate metabolic activity and proliferation with nutrient availability. The PI3K signaling network has been implicated in regulating nutrient acquisition, utilization and biosynthesis, thus integrating receptor-mediated signaling with cell metabolism. In this review, we discuss the current knowledge about metabolic changes induced in activated B cells, strategies to adapt to metabolic stress and the role of PI3K signaling in these processes.

Keywords:

• Akt
• mTOR
• lymphocyte
• glycolysis
• mitochondria

Disclosure statement

The authors report no declarations of interest.

Funding

This study was funded by the National Institutes of Health (AI41649) to RCR and the Excellence Initiative by the German Federal and State Governance (EXC 294) to JJ.