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Review Articles

Miro proteins connect mitochondrial function and intercellular transport

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Pages 401-425 | Received 03 Dec 2020, Accepted 29 Apr 2021, Published online: 17 Jun 2021
 

Abstract

Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discoveries pointing to mitochondria as organelles affecting a number of other auxiliary processes. They go beyond the classical energy provision via acting as a relay point of many catabolic and anabolic processes, to signaling pathways critically affecting cell growth by their implication in de novo pyrimidine synthesis. These additional roles further underscore the importance of mitochondrial homeostasis in various tissues, where its deregulation promotes a number of pathologies. While it has long been known that mitochondria can move within a cell to sites where they are needed, recent research has uncovered that mitochondria can also move between cells. While this intriguing field of research is only emerging, it is clear that mobilization of mitochondria requires a complex apparatus that critically involves mitochondrial proteins of the Miro family, whose role goes beyond the mitochondrial transfer, as will be covered in this review.

Disclosure statement

The authors report no conflict of interest.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This study was supported by grants from the Czech Science Foundation (20-05942S and 21-04607X) and the Czech Health Foundation (17-30138A) to JN, 19-20553S and 20-18513S to JR, BIOCEV European Regional Development Fund (CZ.1.05/1.100/02.0109), and the Institute of Biotechnology financial support (RVO: 86652036). MD was supported by Grant Agency of Charles University (GAUK 1242120).

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