Phytochemical composition, antioxidant and wound healing activities of Teucrium polium subsp. capitatum (L.) Briq. essential oil

ABSTRACT

Teucrium poliumis widely used in Algerian folk medicine as to treat wounds. The aim of this study was to evaluate the chemical composition, antioxidant and wound healing properties of Teucrium polium essential oil. The composition was obtained by a combination of GC-FID and GC-MS analyses. The antioxidant activity was evaluated by in vitro assays (total antioxidant capacity, DPPH and bleaching of β-carotene). The in vivo wound healing potential of an ointment containing 10% of T. polium essential oil was investigated. The main components were in this order: β-pinene, germacrene, α-pinene, myrcene, limonene, bicyclogermacrene, trans-β-guaiene, spathulenol and β-bourbonene. Teucrium polium essential oil  displayed a moderate antioxidant activity. The in vivo experiments showed that 10% OEO accelerated the wound healing process in comparison with controls. This study provides a scientific rationale for the use of Teucrium polium essential oil in the treatments of wounds.

KEYWORDS:

• Teucrium polium
• essential oil
• chemical composition
• antioxidant
• wound healing

Acknowledgments

We wish to thank Mr. Antonio Greco and Ms. Tonia Strano (ICBCNR, Catania), for their skillful technical assistance and Dr. Sarri D. for the plant identification.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Algerian Ministry of Higher Education and Scientific Research (MESRS) [CNEPRU/DO1N01UN280120150001 Project].