Does garlic ameliorates histological alterations of induced mucositis in Albino rats subjected to gamma radiation?

Abstract

The current study aimed to evaluate the effect of garlic on induced oral Mucositis of Albino rats subjected to different gamma radiation doses. All rats were divided into subgroups and irradiated according to the assigned doses except two control groups. The irradiated rats were subjected to induce mucositis in 1, 2 and 3 days after irradiation. Subgroups were orally administered garlic with doses of 500 mg/kg body weight from the beginning of irradiation process. The right buccal mucosa specimens were excised, processed and stained with Hematoxylin and Eosin. Morphometric and Statistical analyses were carried out for epithelial thickness to detect differences between groups. The irradiated subgroups revealed histopathological aggravated changes with applied doses. The garlic succeeded to reduce the histological changes in the buccal mucosa and also to preserve epithelial thickness. Statistically, the epithelial thicknesses were decreased in an inverse relation with irradiation doses. The current study displayed that the garlic administration could help to a great extent to overcome the Mucositis of buccal mucosa resulting from the exposure to different doses of gamma irradiation.

KEYWORDS:

• Garlic
• antioxidant
• histological alterations
• buccal mucosa
• cancer risk

Disclosure statement

No potential conflict of interest was reported by the author(s).