SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME ACRIDINYL AMINO ANTIPYRINE, ACRIDINYL AMINO ANTHRAQUINONE, ACRIDINO THIOUREA AND THIAZOLINO THIOUREA DERIVATIVES

Abstract

9- Chloro - 2(substituted) - acridines (I) on condensation with 4 - amino antipyrine, I-amino anthraquinone and 2 - amino anthraquinone gave corresponding condensed products II, III and IV. Phenyl isothiocyanate reacts with 9 - amino - 2 or 4 (substituted)-acridines (V) and iminothiazolines (VII) to give corresponding N-phenyl -N′- substituted thioureas VI and VIII in good yield. Anti-inflammatory activity screening for IIa, b, In, IV, VIb and VIIIa - I was carried out at 100 mg/kg p.o. and compounds IV, VIIIa, VIIIb and VIIIg-k showed 12, 12, 14, 18, 7, 23, 13 and 18% activity whereas all others were found to be inactive. Analgesic activity screening for IIb, III and IV was carried out at 100mg/kg p.o. Only compound III showed 25% activity whereas IIb and IV were found to be inactive.

Key Words:

• Acridinyl derivatives
• acridino thiourea
• thiazolino thiourea
• antiinflammatory activity
• NMR
• HRMS