p-SUBSTITUTED BENZYL HYDROXYBISPHOSPHONATES: SYNTHESIS AND HYDROLYSIS

Isabelle Mallard Laboratoire de Chimie Structurale Biornoléculaire (UPRES-A 7031 -CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 9301 7, BOBIGNY, Cedex, FRANCE

Jean-Marc Benech Laboratoire de Chimie Structurale Biornoléculaire (UPRES-A 7031 -CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 9301 7, BOBIGNY, Cedex, FRANCE

Marc Lecouvey Laboratoire de Chimie Structurale Biornoléculaire (UPRES-A 7031 -CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 9301 7, BOBIGNY, Cedex, FRANCE

Yves Leroux Laboratoire de Chimie Structurale Biornoléculaire (UPRES-A 7031 -CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 9301 7, BOBIGNY, Cedex, FRANCE

Abstract

Several hydroxybisphosphonate benzyl esters have been synthesized for study. The effect of the benzyl substituent on the acidic hydrolysis of the phosphonic esters has also been studied.

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p-SUBSTITUTED BENZYL HYDROXYBISPHOSPHONATES: SYNTHESIS AND HYDROLYSIS

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p-SUBSTITUTED BENZYL HYDROXYBISPHOSPHONATES: SYNTHESIS AND HYDROLYSIS

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