SYNTHETIC AND BIOLOGICAL STUDIES ON COUMARIN HYDRAZONE DERIVATIVES

Abstract

The reaction of both of coumarin and 6-nitrocoumarin hydrazones (1,4) with alkyl(aryl)isothiocyanate afforded the corresponding 3-N[alkyl(aryl)thioamido] coumarins 3_a-d or benzopyrano[2,3-c]pyrazole-3-thione derivatives 6_a-d , respectively. Compounds (3_a-d) were used as key intermediates for the preparation of benzopyrano-pyridine derivatives (7_a-d & 10_a) or benzopyranoazepine derivatives 8_a,c & 12_a-d through the reaction with different acyl halides or ethoxymethylenemalononitriles and subsequent cyclization. Biological activity of some new compounds against Gram +ve and Gram -ve were given.

Key Words:

• Coumarin hydrazone
• Isothiocyanate
• Ylidenenitriles
• Biological activity