Dimethylsilicon(IV) Derivatives of Amino Acids

Abstract

Reactions of dichlorodimethylsilane with the sodium salt of amino acids in 1:2 molar ratio led to the formation of a new series of dimethylsilicon(IV) complexes of general formula, Me 2 SiL 2 [L = anion of amino acids, viz. glycine (HGly), L-methionine (L-MethH), DL- f -alanine (DL- f -AlaH) L-leucine (L-LeuH), L-valine (L-ValH) and D-phenylalanine (D-PheH)]. The complexes have been characterized by elemental analyses, molar conductance, and electronic spectra, and the bonding in these complexes is discussed in terms of their infrared, 1 H and 13 C NMR spectra. A distorted octahedral structure with trans methyl groups has been tentatively suggested for the complexes. The complexes, found soluble in DMSO, have been tested in vitro against various bacteria, viz. Escherichia coli , Pseudomonas putida-2252 , Aeromonas formicans , Staphylococcus aureus-740 , and fungi, viz. Aspergillus niger ORS-4, Aureobasidium pullulans-1991 , Verticillium dahliae-2063 , and Penicillium notatum-1348 .

Keywords:

• Amino Acids
• Antimicrobial Activity
• Dichlorodimethylsilicon(IV) Complexes
• Multinuclear Nmr