Caro's Acid Supported on Silica Gel. Part V: A Mild and Selective Reagent for Conversion of Trimethyl Silyl ethers to the Corresponding Hydroxy Compounds

Abstract

Mild and efficient method for deprotection of silyl ethers to alcohols is described using Caro's acid supported on silica gel. Reactions are carried out in dichloromethane at room temperature and their parent hydroxy compounds obtained in good to excellent yields. Using this procedure, tetrahydropyranyl ethers (THP) remain intact during desilylation reaction.

We thank the Mazandaran University Council for partial support of this work.

Keywords :

• Caro's acid
• desilylation
• tetrahydropyranyl ethers
• trimethyl silyl ethers

Notes

We thank the Mazandaran University Council for partial support of this work.