A VERSATILE METHOD FOR THE CONVERSION OF ALDOXIMES TO NITRILES USING SILICA GEL/THIONYL CHLORIDE

Abstract

A simple convenient procedure for dehydration of aldoximes has been developed using silica gel/thionyl chloride in heterogeneous conditions. The method has been found to be effective for a wide range of aromatic oximes.

Keywords:

• Aldoxime
• nitrile
• silica gel
• thionyl chloride

The authors acknowledge the partial support of this work by Shahid Chamran Ahvaz University Research Council.

Notes

^a Molar ratio of substrate to reagent was 1:1.5.

^b Yields refer to isolated yields.

^c Products were characterized by comparsion of their physical data, IR, NMR spectra with known samples.