A FAST AND MILD METHOD FOR NITRATION OF AROMATIC RINGS

Abstract

The use of benzyltriphenylphosphonium nitrate (PhCH ₂ Ph₃P⁺NO₃ ⁻) (BTPPN) as a useful reagent for nitration aromatic compounds in the presence of methanesulfonic anhydride under solvent-free conditions is described. This methodology is useful for nitration of activated aromatic rings.

Keywords:

• Aromatic compounds
• benzyltriphenylphosphonium nitrate
• methanesulfonic anhydride
• nitration
• solvent-free conditions

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology, IR Iran (A.R.H.) and grant GM 33138 (A.E.R.) from the National Institutes of Health, USA.

Notes

^a Confirmed by comparison with authentic samples (IR, TLC, and NMR).

^b Molar ratio of 1:2 (1:1).

^c Yield of isolated pure product after purification.