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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 179, 2004 - Issue 4-5
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Original Articles

A NEW APPLICATION OF INORGANIC CLUSTER, CARBORANES FOR MEDICINAL DRUG DESIGN AND MOLECULAR CONSTRUCTION

Yasuyuki Endo Tohoku Pharmaceutical University, Sendai, Japan
,
Kiminori Ohta Tohoku Pharmaceutical University, Sendai, Japan
,
Tomohiro Yoshimi Tohoku Pharmaceutical University, Sendai, Japan
&
Kentaro Yamaguchi Chiba University, Chiba, Japan
Pages 799-802 | Received 01 Aug 2003, Accepted 01 Oct 2003, Published online: 12 Aug 2010
 
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Abstract

The inorganic cage compounds, dicarba-closo-dodecaboranes (carboranes), are chemical building blocks of remarkable thermal and chemical stability, with spherical geometry and exceptional hydrophobic character. We have focused on medicinal drug design using carboranes as a hydrophobic pharmacophore and have developed a potent estrogen agonist, BE120. We also have applied carboranes for structural chemistry, utilizing their specific three-dimensional character to obtain multilayer aromatic structures.

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