SOME ASPECTS ON ACYCLO- 4-[QUINAZOLIN-3-YL]BENZENESULFONAMIDE NON-NUCLEOSIDES SYNTHESIS

Abstract

The reaction of 4-[1,2,3,4-tetrahydroquinazolin-2,4-dion-3-yl]benze-nesulfonamide 4 and 4-[2-thioxo-1,2,3,4 tetrahydroquniazolin-4-on-3-yl]benznesulfonamide 5 with chloromethylethyl ether, chloromethylbenzyl ether, and (2-acetoxyethoxy)methyl bromide afforded compounds 7a–c, 8a,b, and 13 which are analogues to MKC-442, TNK 561, and HEPT.

Keywords:

• Benzenesulfonamide
• MKC-442
• quinazolines
• non-nucleosides
• TNK 561

The authors would like to thank DANIDA establishment Denmark, which supports the project “Development of New Drugs Against Hepatitis” at the Chemistry Department, Faculty of Science, Menoufia University for the laboratory facilities and spectroscopic measurements.

Notes

*MKC-442 demonstrating higher synthestic anti-HIV activity with AZT than neuirapine will soon enter clinical studies.