Abstract
A new, universal, and versatile method has been developed for the synthesis of the chiral α,β-unsaturated N-acyl-oxazolidin-2-ones 4 based on the Wittig reaction of the triphenylphosphonium salt 7 derived from the (R)-3-(2-Chloro-acetyl)-5,5-dimethyl-4-phenyl-oxazolidin-2-one 6.
The authors are grateful to Guilan University Research Council for financial support of our research program.
Notes
a All products were analyzed by comparison of their physical and spectroscopic data (1H NMR, IR) with those of authentic samples.
b Yields are based on isolated products.