Abstract
Acrolyl furochromen-2-ones (3a–i) obtained in good yields on microwave irradiation of furochromen-2-one (1) with various simple and substituted aromatic aldehydes (2a–i). 3a–g on cyclo dehydration with thiourea in domestic microwave oven furnished tetrahydro thiaxopyrimidine furochromen-2-ones 4a–i in high yields. The structures of the newly synthesized compounds were established on the basis of analytical and spectral data, IR, and 1H NMR.
Acknowledgments
The authors are thankful to UGC for the financial assistance, and greatly thankful to Dr. Kirity Roy, Principal Research Scientist, Nicholas Piramal India Limited for screening anti-microbial activity of the compounds. The authors are also thankful to Director IICT Hyderabad for providing NMR spectra.