AN EFFICIENT SYNTHESIS OF DIHYDRO SELENOLO (2,3-b)QUINOLINE-2-CARBOXYLIC ETHYL ESTERS AND 2-SELENOXO-1, 2-DIHYDRO-3-CARBETHOXY ETHYL QUINOLINES—THEIR ANTI-BACTERIAL STUDIES

Abstract

The compounds dihydro selenolo(2,3-b)quinoline-2-carboxylic ethyl esters and 2-selenoxo-1, 2-dihydro-3-carbethoxy ethyl quinolines were synthesized in varying yields upon reacting 3-(2-chloro-3-quinolyl)acrylic methyl esters with the nucleophilic reagent sodium hydrogen selenide in ethanol medium under nitrogen atmosphere.

Keywords:

• Condensation
• cyclization using NaHSe in absolute ethanol
• dehydroxychlorination
• esterification
• hydrolysis
• Vilsmeier-Haack Reaction

ACKNOWLEDGEMENT

We wish to thank Bharathiar University for the award of URF to one of us (V. N). We also thank the services rendered by the Dept of Chemistry Bharathiar University at Coimbatore, IICT at Hyderabad and Sophisticated Instumentation facility at IISc Bangalore for recording elemental analysis, Proton NMR, IR and Mass spectra. We greatly acknowledge Dr. P. Lakshmanaperumalsamy and Mr. Subashkumar-Division of microbiology, Dept of Environmental Sciences, Bharathiar University, Coimbatore, for the microbial studies rendered by them.