Reactivity of N¹-Dithioester Substituted Pyridinand Pyrazincarboxamidrazones

The N ¹-dithioester substituted pyridin- and pyrazincarboxamidrazones underwent cyclocondensation to 5-methylsulfanyl-1,3,4-thiadiazole or 1,2,4-triazole derivatives, depending on the reaction conditions. With an excess of secondary amines, pyrazincarboxamidrazone dithioester gave 5-amino-1,3,4-thiadiazoles and with an ethanoloamine a 1,2,4-triazole derivative. Prepared compounds were evaluated as potential tuberculostatic agents, but the minimum inhibitory concentrations values indicated no significant activity.

keywords:

• 1,2,4-triazoles
• 1,3,4-thiadiazoles
• amidrazones
• hydrazinecarbodithioic acid esters
• tuberculostatics

Acknowledgments

We are grateful to Dr. P. Sowinski, Technical University of Gdansk, for recording and discussing 2D-NMR spectra.