Synthesis and Antimicrobial Activity of Thioxopyrimidines and Related Derivatives

The interaction of thiourea with activated cyanoolefins under different reaction conditions were studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, & 21) and related derivatives (10, 11, 14, 16, & 17) were obtained respectively. Also, the reactions of thiopyrimidines (8, 9) with different electrophilic and nucleophilic reagents were reported. IR, ¹H NMR, ¹³ C NMR and mass spectra for the newly synthesized compounds were studied. Most of the obtained compounds were screened against Gram-postive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results.

Keywords:

• Activated nitriles
• antimicrobial activities
• (1H-pyrazol-1-yl)pyrimidine
• [(pyrimidin-2-yl)disulfanyl] pyrimidine
• thiourea
• thioxopyrimidines

Notes

*(lit. ³⁴ m.p. 231–232).

**(lit. ³⁷ m.p. 279–280).