Rapid Synthesis of N-Acyl Ureas from Their Thio Analogues Using Wet Silica-Supported Permanganate Under Solvent-Free Conditions

Abstract

A rapid method to N-acyl ureas from corresponding N-acyl thioureas is described. N-coumaroyl-N′-arylthioureas, which are easily prepared by the reaction of coumarin-3-carboxylic acid chloride with potassium thiocyanate and arylamines, can be expeditiously transformed into corresponding N-acyl ureas via r.t. grinding with wet silica supported potassium permanganate under solvent-free conditions in an excellent yield.

Keywords:

• N-acyl urea
• N-acyl thiourea
• potassium permanganate
• solvent-free

The authors thank the Chun-Hui Project of the Minister of Education of China (Z2004- 1-62034) for the financial support of this work.