Various aldehydes have been protected with different thiols as dithioacetals with excellent yields using anhydrous copper sulfate as a mild and chemoselective catalyst. The reaction is carried out in a solvent and/or under solvent-free conditions. The transthioacetalization of oxyacetals into dithioacetals was also achieved in an excellent yield.
Notes
a All yields refer to isolated products, and all products were characterized by m.p., IR, and 1H-NMR. Their physical data were similar to those reported in the literature.
b Dichloromethane as a solvent.
c Solvent-free conditions.