The Synthesis of Some New Sulfur-Bearing Various Heterocyclic Systems Derived from Asymmetrical N,N′-Disubstituted Thiourea Derivatives

The heterocyclization of an asymmetrical N,N′-disubstituted thiourea (1a–d) in ring closure reactions with Br₂/AcOH, ethyl chloroacetate, diethyl oxalate, diethyl malonate, and hydrazine hydrate led to the direct formation of sulfur-bearing various heterocyclic systems (2–8) in which the thiaenolization is toward the aryl group. The synthetic work and reactivity investigations have been well supported by standard modern spectroscopic techniques (IR, ¹ H NMR, ¹³ C NMR, mass spectrum, and microanalysis).

Keywords:

• Asymmetrical N,N′-disubstituted thiourea
• benzo[d]thiazole
• thiazolidin-4-one
• thioxoimidazol-4,5-dione