The Synthesis of Some New Sulfur Heterocyclic Compounds as Potential Radioprotective and Anticancer Agents

Some novel 5-subistituted amino-3-methylthiophene-2,4-dicarboxylic acid diethyl ester (3–6), 3,5-dimethyl-4-oxo-2-thioxo-1,2,3,4-tetra-hydro-thieno[2,3-d]pyrimi-dine (7), imidazothienopyrimidene (8), and 1,2,4-triazolo-thienopyrimidine (11) were synthesized via a reaction of the isothiocyanate 2 with different reagents. The identification of the new compounds was established by elemental analysis, and IR, ¹H NMR, and mass spectral data. Some prepared compounds were tested for their radioprotective and anticancer activities. Compounds 7 and 16 showed significant activities against EAC cells, while compound 5 exhibited radioprotective activity.

Keywords:

• Radioprotective and anticancer activities
• thieno[2,3-d]pyrimidines

Notes

*Each value represents the mean of six-observations ±SE (7 days after radiation exposure).

†A significant of change between groups.

†Each value represents the mean of six-observations ± SE (7 days after radiation exposure).

*A significant of change between groups and control.

†Each value represents the mean of six-observations ± SE.

*A significant of change between groups and control.