Abstract
The synthesis of novel thioureido derivatives 3, 8, and 10; biscompounds 7, 9, and 11; and tetracyclic compounds 5, 6, and 16 utilizing 5-isothiocyanato-3-methyl-thiophene-2,4-dicarboxylic acid diethyl ester 2 are reported. The structures of these compounds were confirmed by microanalyses and IR, 1H NMR, and mass spectroscopy. Preliminary biological studies of some of the synthesized compounds showed promising radioprotective and anticancer activities.
Notes
†Each value represents the mean of six-observations ± SE (7 days after radiation exposure).
*Significance of change between groups.
†Each value represents the mean of six-observations ± SE (7 days after radiation exposure).
*Significance of change between groups and control.
†Each value represents the mean of six-observations ± SE.
*Significant of change between groups and control.