Asymmetric Cyclic Phosphorothonamides Containing Substituted Pyridine

Abstract

In order to find high-acitivity and low-toxicity pesticidal lead compounds, a type of novel, asymmetric cyclic phosphorothonamides containing substituted pyridine were synthesized via the condensation reactions of 2-chloro-4-substitutedphenyl-5,5-dimethyl-1,3,2-dioxaphosphinane 2-sulfide with 3-aminomethylpyridine. The cis and trans isomers of the products were isolated by column chromatography on silica gel. The structures of the products were characterized by ¹ H NMR, ³¹ P NMR, MS, and elemental analyses. The configuration of 3a was determined by X-ray diffraction analysis. The results of the preliminary bioassay showed that the new compounds possess potential fungicidal activities.

Keywords:

• Cyclic phosphorothonamide
• fungicidal actitity
• substituted pyridine
• X-ray diffraction

Acknowledgments

We are grateful to the Natural Science Foundation of China (20302002) for financial support.