Synthesis and Bioassay of Phosphorylated and Thiphosphorylated Derivatives of Substituted Benzothiazoles

Abstract

Phosphorylated and thiophosphorylated benzothiazole derivatives have been synthesized by a reaction of phosphorus oxychloride/phosphorus thiochloride with 1,2-bis(2-benzothiazolyl)ethanol in 1:1, 1:2, and 1:3 molar ratios in the presence of triethylamine. Plausible structures have been proposed on the basis of elemental analysis IR, ¹H NMR, and ³¹P NMR spectral studies. The fungicidal activity of these derivatives has been evaluated against pathogenic fungi Aspergillus niger and Fusarium oxysporium. The fungicidal data reveals that these compounds are more fungitoxic than the parent 1,2-bis(2-benzothiazolyl)ethanol compound.

Keywords:

• Benzothiazole
• fungicidal activity
• phosphorylated derivatives
• phosphorylation