Synthesis and Reactions of Some Novel Quinoxalines for Anticancer Evaluation

Abstract

1,2-Dihydro-3-(2 ′-naphthyl)quinoxaline-2-one ( 4 ) was prepared from the reaction of methyl(2 ′-naphthyl)glyoxylate ( 3 ). Also, 2-chloro-and 2-hydrazinoquinoxaline derivatives 5 and 6 were prepared, which, upon reacting with different reagents, afforded the triazolo, tetrazolo, and amino quinoxaline derivatives. Compounds 5 , 8b , 9 , 10b , and 11b were evaluated for their anticancer activity.

Keywords:

• Acetyl naphthalene
• anticancer evaluation
• hydrazinoquinoxaline
• quinoxalinone