Synthesis and Characterization of Novel Phospholane Heterocycles

Abstract

Phospholanes are a unique class of cyclic organophosphorus compounds, which have marked applicability in medicinal science, agroscience, and catalytical chemistry. Using phosphorus trichloride as a phosphorylating agent, fourteen novel chiral cyclic organophosphorus derivatives were achieved using different 2-aminocycloimines as starting material. The resulting five-membered cyclic derivatives have shown the ABCX₃ system associated with one phosphorus nucleus in ¹H NMR. The present study thus describes a novel synthetic strategy for phospholanes, which are analogous to cyclophosphamides.

Keywords:

• Bifunctional nucleophiles
• cyclophosphamides
• phospholane
• phosphorylation

Acknowledgments

We are highly grateful to the Head, Department of Chemistry, University of Rajasthan, for recording a number of spectra and for providing all of the necessary facilities.