New Types of Mono and Bis Sulfonamides, Tosylamino Acids and Thiosulfonic Ester Derived from Xanthotoxin, Bergapten and Visnagin with Biological Interest

Abstract

Xanthotoxin, bergapten, and visnagin sulfonyl chlorides have been reacted with diamines, hydrazine, amino acides, and imidazolidineiminothiones to produce the corresponding mono-, bis-sulfonamide, and tosylamino acid derivatives. Interaction of xanthotoxin-4-sulfonyl chloride with thiohydantoin furnished the respective thiosulfonic ester. The new products exhibited better antibacterial and antifungal activities.

Keywords:

• Bergapten
• imidazolineiminothiones
• tosylamino acids
• thiohydantoin
• visnagin
• xanthotoxin

Acknowledgments

The authors wish to express their thanks and sincere gratitude to Prof. Dr. M. M. El-Nozhah, president of Taibah University and Dr. A. A. El-Harby, Dean of Faculty of Science, Taibah University for their great help to Research programs.