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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 182, 2008 - Issue 10
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Original Articles

The Synthesis of Distamycin Analog Containing Phosphonyl Group

Yong Ye Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China; Key laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, China
,
Shang-Bin Zhong Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China
,
Ruo-Yu Liu Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China
,
Li-Feng Cao Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China
,
Cun-Jiang Liu Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China
,
Jun-Liang Yang Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou, China
&
Yu-Fen Zhao State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China
 show all
Pages 2251-2257 | Received 02 Mar 2007, Accepted 09 Apr 2007, Published online: 23 Aug 2007
 
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Abstract

In order to obtain high biological activity compound, a series of distamycin analog containing phosphonyl group were synthesized by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives.

Acknowledgments

The authors would like to thank the Chinese National Science Foundation (No. 20602032), Education Department of Henan Province, and Zhengzhou University for financial support.

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