Convenient Synthesis and Antimicrobial Evaluation of Multicyclic Thienopyridines

Abstract

Thieno[2,3-b]pyridines 7, 8, and 10 could be obtained via the S-alkylation of 3-cyano-4,6-di-2-furyl-2(1H)pyridinethione (3) with a variety of alkylating agents. These compounds were conveniently converted into novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines 12–15 and 17–20 and thieno[2,3-b;4,5-b′]dipyridine 11 derivatives. Structures of the products have been determined by elemental analyses and spectral data studies. All the tested compounds were found to exhibit moderate antimicrobial activity.

Keywords:

• Multicyclic pyridines
• pyridothienopyrimidine
• thienodipyridine
• thienopyridine

Notes

^a Compound 15 is the only one that exhibited inhibition (15.8%) against Aspergillus flavus among the tested compounds;

^b 100% inhibition means no growth of either bacteria or fungi allover the plate.