Abstract
Fourteen novel organothiophosphonates incorporating pyrimidine heterocycles have been synthesized through an economical synthetic strategy. The products were well characterized through different spectral techniques. The 1 H NMR spectra have shown interesting diastereotopic properties thus, showing chirality in the molecule. The chlorothiophosphonates were the first step products which were further substituted to several other products through nucleophilic substitution reaction. This study has shown unique prospects for synthesis of chiral molecules.
We are grateful to Head, Department of Chemistry, University of Rajasthan, Jaipur, for providing necessary facilities.