Synthesis and Biological Activity on Some Organoantimony (III) Compounds

Abstract

Organoantimony (III) amides of the type Ar₂SbL; (Ar = C₆H₅, C₆F₅, C₆H₄F; L = succinimide and phthallimide) were synthesized and assayed for their biological activities. These compounds exhibited significant in-vitro antitumor activity against human breast adenocarcinoma cell line (MCF-7), mammary cancer cell line (EVSA-7), and antibacterial activity against human pathogenic bacteria viz. Pseudomonas aeruginosa, Staphylococcus aureus, and Klebsiela pneumoniae. These compounds also exhibited remarkable antifungal activity against Aspergillus flavus and Aspergillus niger strains.

Keywords:

• Antibacterial
• antifungal activity
• antitumor
• organoantimony (III) amides

Acknowledgments

The authors are thankful to the Director, Hygia Institute of Pharmaceutical Education & Research (HIPER), Lucknow for providing necessary laboratory facilities; Director NBRI and CDRI Lucknow for antimicrobial and antitumor activity and RSIC, CDRI for analysis of the compounds.