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Abstract
In this presentation, we will outline our novel, integrated bead-based oligonucleotide selection procedures including the automation of the split-pool synthesis of a one-bead one-thioaptamer library, high-throughput flow cytometric sorting and a PCR-based sequencing. Additionally, we will also discuss one promising thioaptamer that has been shown in preliminary animal therapeutic dosing to increase survival in animal models of infection with West Nile virus. Moreover, we will present our ongoing work on a thioaptamer proteomics chip.
Acknowledgments
This research was supported by grants to Dr. Xianbin Yang from Mike Hogg Fund and NIH (1R03CA121353-01); to Dr. David Gorenstein from DARPA (P42296LS0000), NIH (U01 A1054827, IP30 ES06676; N01 HV28184; UO1 AI 60616), DoD (DADD13-02-C-007 and contract number W911 SR-04-C-0065 with the U.S. Edgewood Chemical Biological Center), the Welch Foundation (H-1296), and the State of Texas Advanced Technology Program (004952-0038-2003).