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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 183, 2008 - Issue 2-3
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Original Articles

Synthesis of Novel Steroidal Bioconjugates of Phospholipid with AZT

Pei-Yuan Jin Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
,
Kai Liu Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
,
Yong Ju Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
&
Yu-Fen Zhao Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P. R. China
Pages 538-542 | Published online: 20 Jun 2008
 
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Abstract

Some novel asymmetry steroidal bioconjugates of phospholipid with AZT were synthesized by oxidation or conjugation with amines using Atherton–Todd reaction, and the structures were confirmed based on spectral methods. The result shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.

Acknowledgments

Project supported by the NSF of China (No. 20542004, 20772071) and SRFDP of Higher Education (No. 20050003104).

Notes

a Based on the reactant AZT.

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