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Original Articles

Synthesis of Novel Steroidal Bioconjugates of Phospholipid with AZT

, , &
Pages 538-542 | Published online: 20 Jun 2008
 

Abstract

Some novel asymmetry steroidal bioconjugates of phospholipid with AZT were synthesized by oxidation or conjugation with amines using Atherton–Todd reaction, and the structures were confirmed based on spectral methods. The result shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.

Acknowledgments

Project supported by the NSF of China (No. 20542004, 20772071) and SRFDP of Higher Education (No. 20050003104).

Notes

a Based on the reactant AZT.

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