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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 183, 2008 - Issue 2-3
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Original Articles

Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies

A. Vovk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
V. Kalchenko Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine
,
O. Muzychka Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
V. Tanchuk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
I. Muravyova Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
A. Shivanyuk Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine
,
S. Cherenok Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine
&
V. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
 show all
Pages 625-626 | Published online: 21 Jun 2008
 
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Abstract

The inhibition of alkaline phosphatase from bovine intestine mucosa and bovine kidney by calix[4]arenes functionalized at the marcocyclic upper rim by one or two methylene bisphosphonic acid fragments have been investigated. The mechanisms of enzyme inhibition have been discussed using a molecular docking approach by computational modeling of inhibitors into active centers of E. coli alkaline phosphatase.

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