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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 183, 2008 - Issue 2-3
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Original Articles

Bio-Relevant Derivatives of Calixarene Phosphonic Acids

S. Cherenok Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine
,
A. Vovk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
I. Muravyova Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
A. Marcinowicz Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
,
J. Poznanski Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
,
O. Muzychka Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
V. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine
,
W. Zielenkiewicz Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
&
V. Kalchenko Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine
 show all
Pages 638-639 | Published online: 20 Jun 2008
 
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Abstract

The calix[4]arenes functionalized at the macrocyclic upper rim with α-hydroxyphosphonic, α-aminophosphonic or methylnebisphosphonic acid groups were synthesized. The complexes formed between the bio-relevent calix[4]arene derivatives and amino acids or dipeptides as well as inhibition effects of calix[4]arene phosphonic acids on alkyline phosphatases acitiy were studied.

Acknowledgments

The work is supported by the President of Russian Federation program (MK-2444.2007.3).

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