Abstract
A study on Mannich type reaction synthesis of Diphenyl α-[phenyl N,N-bis(2-chloroethyl) phosphorylamino]methylphosphonates has been carried out. Their geometric stereoisomers were isolated and characterized. The reaction was catalyzed by acetyl chloride and good to excellent yields were obtained under these reaction conditions.
Acknowledgments
The authors would like to thank the Committee of Science and Technology of Tianjin (07JCZDJC04800) and Nankai University (J02044 to Z. W. Miao) for financial support.