Synthesis and Biological Activity of a Novel Compound: (C₆F₅)₂SbPh

Abstract

A novel organoantimony compound “(C₆F₅)₂SbPh” was synthesized in high yields by modified method and evaluated for insecticidal and antimicrobial activities. The compound was very effective against polyphagous insect pest of crops Spodoptera litura (Lepidoptera: Noctuidae) and polyphagous mite pest of crops Tetranychus urticae (Tetranychidae: Acari). The LC₅₀ value for Spodoptera litura was 0.187 (μ g/insect) and 0.385% respectively in topical application and leaf dip methods. The compound also showed very high antifeedant activity against Spodoptera litura (EC₅₀: 0.155%). The LC₅₀ value against Tetyranychus urticae was 0.021%. Antibacterial activity of the compound (1%) was also tested against human pathogenic bacteria Klebsiella pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa showed inhibition zone of 19.78 ± 0.44, 25.49 ± 0.73, and 19.71 ± 0.74 mm, respectively. The minimum inhibitory concentration (MIC) of the novel organoantimony compound against fungi Aspergillus flavus was 125 μ g/mL.

Keywords:

• (C₆F₅)₂SbPh
• Antimicrobial
• Aspergillus flavus
• insecticidal
• Klebsiella pneumoniae
• Pseudomonas aeruginosa
• Spodoptera litura
• Staphylococcus aureus
• Tetranychus urticae

Acknowledgments

The authors are thankful to the Head, Chemistry Department, Lucknow University, Lucknow, for providing necessary laboratory facilities; Director NBRI, Lucknow, for Insecticidal and antimicrobial activity and RSIC, CDRI Lucknow for analysis of the compounds.