Abstract
A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl3. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, 1H NMR, 13C NMR, and mass spectra.
Acknowledgments
The authors are thankful to Dr. K C Patel and Mr. Kishor H Chauhan, Department of Biosciences, Sardar Patel University, for providing facilities for the antibacterial activity and SAIF, Punjab University, for 1H NMR and 13C NMR Spectra.