Abstract
Novel organophosphorus compounds have been conveniently prepared using 2-(2′-hydroxynapthyl)benzoxazole and 2-(2′-aminophenyl)benzoxazole as starting materials. Phosphorylation and thiophosphorylation was performed using different molar ratio (1:1, 1:2 and 1:3) of phosphorus oxychloride/thiophosphoryl chloride and substituted benzoxazole. The toxicity of newly synthesized phosphorylated/thiophosphorylated compounds was tested on Aspergillus niger and Fusarium oxysporium. All were found antifungal agents. Plausible structures have been proposed on the basis of IR, 1 H NMR, 31 P NMR spectral studies.
Acknowledgments
We are grateful to the head of the Department of Chemistry, University of Rajasthan, Jaipur for providing necessary facilities. Mahesh Kumar Samota is grateful to the council of scientific and Industrial Research (CSIR), New Delhi, India, for financial support in the form of direct senior Research Fellow vide ground. No. 9/149(325)/2K3-EMR-I.