Synthesis and Antimicrobial Activities of Some Novel Pyrido[2,3-d]pyrimidine Derivatives

Abstract

2-Amino-(6-phenoxathiin-2-yl)-4-phenyl-nicotinonitrile has been synthesized and used as a starting material to construct a novel series of annulated and substituted pyrido[2,3-d]pyrimidine systems. Antibacterial and antifungal activities of some synthesized compounds were evaluated and reported.

Keywords:

• Antimicrobial activity
• phenoxathiin
• pyrido[2,3-d]pyrimidines

Acknowledgments

All strains were kindly supplied from the Botany Department, Faculty of Science, Benha University, Egypt.

Notes

^a Inhibition zone diameter d of either fungal growth or bacterial cells for each compound: +++ > 12 mm, highly active; ++ > 9 mm, moderately active; + > 7 mm, slightly active; − no inhibition observed.