Abstract
The behavior of the 2-methylthio-pyrimido[4,5-b]quinolin-4-one towards differently substituted amines is reported. Also, the reactivity of 3-aminothiazolo[3′,2′ :1,2]-pyrimido[4,5-b]quinoline-2-carbonitrile towards formic acid, urea, thiourea, formamide, and carbon disulfide is discussed. Some of the synthesized derivatives possess biological activities as anti-inflammatory and analgesic agents. Some of these selective biologically active compounds were screened for antioxidant properties.
Notes
∗p < 0.5,
∗∗ p < 0.001 as compared with respective control.
aP < 0.05: Statistically significant from control (Dunnett's test).
bP < 0.05: Statistically significant from ASA (Dunnett's test).
∗ p < 0.5,
∗∗ p < 0.001 as compared with respective control.