Synthesis of 5-Thioxo-hexahydrobenzo[b]thiopheno[2,3-d]-1,2,4-triazolo[1,5-c]pyrimidines and Related Compounds Based on Cyclocondensations of 2-Isothiocyanato-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene

Abstract

5-Thioxo-4,6,8,9,10,11-hexahydro-benzo[b]thiopheno[2,3-d]-1,2,4-triazolo[1,5-c]pyrimidines and related compounds were prepared based on cyclizations of 2-isothiocyanato-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene with aminoketones and carboxylic hydrazides.

Keywords:

• Cyclizations
• heterocycles
• isothiocyanates
• nitriles

Financial support from Boehringer Ingelheim Pharma GmbH & Co. KG, from the DFG, and from the state of Mecklenburg-Vorpommern is gratefully acknowledged.

Notes

^a Isolated yields.

^a Isolated yields

^b experiment not carried out.