Abstract
Silica gel–supported ceric ammonium nitrate (CAN-SiO 2 ) has been found to be an effective reagent for the solid–solid phase and solvent-free N-dearylation of β-lactams. The results have been compared with CAN alone in solution and solid–solid phase.
The authors thank the Shiraz University Research Council for financial support (Grant No. 86-GR-SC-23).
Notes
a Based on unreacted starting material.
a In CH3CN/H2O (3:1) by 3.0 eq. of CAN for 45 min.
b By 3.5 eq. of CAN for 30 min.
c In CH3CN/ H2O (3:1) by 2.5 eq. of CAN for 30 min.
d By 2.5 eq of CAN for 20 min.
∗Compounds marked by an asterisk are new.