Synthesis, Spectral, and 3D Molecular Modeling of Tin(II) and Organotin(IV) Complexes of Biologically Active Schiff Bases Having Nitrogen and Sulfur Donor Ligands

Abstract

Reaction of tin(II) chloride and dimethyltin dichloride with Schiff bases derived from S-benzyldithiocarbazate leads to the formation of a new series of tin(II) and organotin(IV) complexes of general formula SnCl ₂ .L and Me ₂ SnCl ₂ .L (where L = Schiff bases are derived from the condensation of S-benzyldithiocarbazate with heterocyclic aldehydes). An attempt has been made to prove the structures of the resulting complexes on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, and multinuclear magnetic resonance ( ¹ H, ¹³ C, and ¹¹⁹ Sn NMR) spectral studies. A few representative ligands and their tin complexes have also been screened for their antibacterial and antifungal activities and found to be quite active in this respect.

Keywords:

• Antimicrobial activity
• complexes
• dimethyltin dichloride
• dithiocarbazate
• heterocyclic aldehydes
• spectral studies
• tin(II) chloride

The author is thankful to CSIR, New Delhi, for financial assistance. The author is also grateful to Dr. A. K. Varshney, Department of Chemistry, University of Rajasthan, for encouragement and help.