Abstract
New 3,4-dihydropyrimidin-2-ones having a phenyl moiety at C-5 and C-6 have been prepared by a microwave-assisted Biginelli–like reaction by a three-component, one-pot condensation of an aromatic aldehyde, deoxybenzoin and urea, or thiourea using TMSCl and Co(OAc) 2 .4H 2 O as an efficient Lewis acid catalyst.
Notes
∗ Reaction condition: 3-methoxybenzaldehyde 5 mmol, deoxybenzoin 5 mmol, urea 15 mmol, P = 300 W, DMF.
∗ Reaction condition: 3-methoxybenzaldehyde 5 mmol, deoxybenzoin 5 mmol, urea 15 mmol, Co(OAC)2.4H2O 0.25 mmol, and TMSCl 2.5 mmol, DMF.
∗ Reaction condition: aromatic aldehyde 5 mmol; ketone or β-ketoester 5 mmol; urea15 mmol or thiourea 12 mmol, Co(OAc)2.4H2O 0.25 mmol and TMSCl 2.5 mmol, DMF, P = 300 W.